The eukaryotic signal sequence, YGRL, targets the chlamydial inclusion
نویسندگان
چکیده
منابع مشابه
The eukaryotic signal sequence, YGRL, targets the chlamydial inclusion
Understanding how host proteins are targeted to pathogen-specified organelles, like the chlamydial inclusion, is fundamentally important to understanding the biogenesis of these unique subcellular compartments and how they maintain autonomy within the cell. Syntaxin 6, which localizes to the chlamydial inclusion, contains an YGRL signal sequence. The YGRL functions to return syntaxin 6 to the t...
متن کاملProteins in the chlamydial inclusion membrane.
The chlamydiae are obligate intracellular pathogens that occupy a nonacidified vacuole (the inclusion) during their entire developmental cycle. Several proteins have recently been identified that are localized to the inclusion membrane. The following is a discussion of how inclusion membrane proteins might participate in the chlamydial developmental process.
متن کاملThe trans-Golgi SNARE syntaxin 6 is recruited to the chlamydial inclusion membrane
Chlamydia trachomatis is an obligate intracellular pathogen that replicates within a parasitophorous vacuole termed an inclusion. The chlamydial inclusion is isolated from the endocytic pathway but fusogenic with Golgi-derived exocytic vesicles containing sphingomyelin and cholesterol. Sphingolipids are incorporated into the chlamydial cell wall and are considered essential for chlamydial devel...
متن کاملLate endocytic multivesicular bodies intersect the chlamydial inclusion in the absence of CD63.
Chlamydiae are obligate intracellular bacterial pathogens that replicate solely within a membrane-bound vacuole termed an inclusion. Within the confines of the inclusion, the replicating bacteria acquire amino acids, nucleotides, and other precursors from the host cell. Trafficking from CD63-positive multivesicular bodies to the inclusion was previously identified as a novel interaction that pr...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2014
ISSN: 2235-2988
DOI: 10.3389/fcimb.2014.00129